Genetic predisposition
Genetic predisposition - Dr. Cindy Boer
The development of ME/CFS may be determined for 48–56% by a person’s hereditary predisposition, in other words, their genetic (DNA) background. This has not yet been thoroughly investigated, even though genetic research is known to help identify the cause of ME/CFS. The aim of this genetic study (a Genome-Wide Association Study, GWAS) is to discover DNA variations that occur more frequently, or exclusively, in people with ME/CFS.
To achieve this, a large, worldwide collaboration will be established with existing (population) studies that include data from ME/CFS patients. By combining the identified DNA variations with other biological data collected in MECFS Lines, the genes and biological mechanisms underlying ME/CFS can be mapped. The next step is to examine whether there are already existing medications that act on these genes and biological mechanisms. Such medications could potentially be repurposed as treatments for ME/CFS.
Dr. Cindy Boer
Cindy Boer works at the Laboratory for Population Genomics in the Department of Internal Medicine at Erasmus MC in Rotterdam.
Other Projects
Antibodies
The immune system, or defense system, protects our body against intruders such as viruses and bacteria. There is evidence that disrupted immune responses are involved in ME/CFS.
Post-Exertional Malaise (PEM)
People with ME/CFS experience a worsening of their symptoms after exertion, and this can last for a long time. This is called post exertional malaise (PEM).
Gut Microbiome
By gut microbiome we mean the microorganisms, such as bacteria, fungi, and viruses, that live in the intestines.
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