Gut Microbiome
Gut Microbiome - Dr. Alexander Kurilshikov
By gut microbiome we mean the microorganisms, such as bacteria, fungi, and viruses, that live in the intestines.
The gut microbiome plays a role in regulating various functions in the body. It also influences the immune system and brain function. There is evidence that the gut microbiome may contribute to the development of ME/CFS. These indications come from earlier studies on this relationship, but those studies had few participants, were short in duration, or had other limitations.
The researchers in this project are mapping the gut microbiome of 900 people with ME/CFS. They are also using existing gut microbiome data from 8,000 people without ME/CFS. All of these individuals participate in the Lifelines Study, which includes information on diet, lifestyle, and any medications used by participants. All factors these factors can influence the gut microbiome.
More knowledge about the gut microbiome composition of people with ME/CFS may provide new insights into how the disease develops. This may ultimately contribute to improved diagnosis and to the development of microbiome targeted treatments for ME/CFS.
Dr. Alexander Kurilshikov
Alexander is a member of the first research group to study, on a large scale, how the gut bacteria of humans vary due to factors such as diet, medications, diseases, and overall health
Other Projects
Antibodies
The immune system, or defense system, protects our body against intruders such as viruses and bacteria. There is evidence that disrupted immune responses are involved in ME/CFS.
Post-Exertional Malaise (PEM)
People with ME/CFS experience a worsening of their symptoms after exertion, and this can last for a long time. This is called post exertional malaise (PEM).
Genetic predisposition
The development of ME/CFS may be determined for 48–56% by a person’s hereditary predisposition, in other words, their genetic (DNA) background.
Partners
